Jeong Lab

Emily Y. Park ‘19,Kaitlyn M. Tsuyuki ‘18,  Fengling Hu ‘19, Joohyun Lee, and  Jeeyon Jeong

Front. Plant Sci., May 2019


Iron is an essential micronutrient for nearly all organisms, but excessive iron can lead to the formation of cytotoxic reactive oxygen species. Thus, plants have evolved complex mechanisms to optimize their use of iron. Our study adds novel insights to the transcriptional regulation of iron homeostasis in plants by showing that chromatin remodeling via histone 3 lysine 27 trimethylation (H3K27me3) modulates the expression of FIT-dependent genes under iron deficiency. We propose that H3K27me3 attenuates the induction of FIT-target genes under iron deficiency and hypothesize that this may serve as a mechanism to restrict the maximum level of induction of iron acquisition genes to prevent iron overload.


Proposed model for H3K27me3 regulation of the FIT-dependent iron deficiency response