Haneui Bae, Shirui Chen, John P. Roche, Minrong Ai, Chunlai Wu, Aaron DiAntonio, & Ethan R. Graf

eNeuro, March/April 2016, 3(2) e0031-16.2016, 1-19

Loss of rab3-GEF results in a phenotype indistinguishable from the rab3 mutant.

  Rab3-GEF 1.jpg

Our findings suggest that although Rab3-GEF acts upstream of Rab3 to control Rab3 localization and likely GTP-binding, it also acts downstream to regulate active zone development, potentially as a Rab3 effector at the synapse.

  Rab3-GEF 2.jpg